Jun. 30, 2025
A review found reports that compounds found in mulberry leaves may help lower blood sugar, cholesterol, and inflammation levels. However, more research is necessary to assess the efficacy of mulberry leaf and its extracts in treating these conditions fully.
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While some people may find benefits from using herbal remedies alongside doctor-recommended treatments, their use should never replace medical therapies.
Mulberry leaves provide several compounds that may help combat diabetes. These include 1-deoxynojirimycin (DNJ), which prevents the absorption of carbs in your gut.
In one placebo-controlled study, 37 adults ingested maltodextrin, a starchy powder that rapidly boosts blood sugar levels. They were then given mulberry leaf extract containing 5% DNJ. Those who took either 250 or 500 mg of the extract experienced a significantly lower rise in blood sugar and insulin levels than the placebo group.
Another study from reported that over a 3-month period, people with type 2 diabetes who took 1,000 mg of mulberry leaf extract 3 times daily with meals experienced significant reductions in post-meal blood sugar levels, compared with a placebo group.
However, it is important to note that further study is necessary to fully assess the efficacy of mulberry leaf and its extracts as a complementary diabetes treatment.
Some research suggests that mulberry leaf extract may improve heart health by reducing cholesterol and blood pressure levels, decreasing inflammation, and preventing atherosclerosis — a buildup of plaque in your arteries that can lead to heart disease.
For example, a review reports that compounds found in the mulberry leaf may have several different positive effects, including:
However, it is important to note that many of the studies cited in the review are older and may include test tube and animal studies rather than controlled human trials. As a result, while this potential therapy area may be promising, there is a current lack of high-quality clinical evidence supporting the use of mulberry leaf and its compounds for these means.
For example, animal studies indicate that this leaf may prevent atherosclerosis, reduce cellular damage, and lower blood pressure, all of which are risk factors for heart disease. However, these effects have not been appropriately replicated in controlled human studies.
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Mulberry leaves contain numerous anti-inflammatory compounds, including flavonoid antioxidants. Some research suggests that mulberry leaf may combat inflammation and oxidative stress, both of which are linked to chronic disease.
For example, a study in mice on high fat diets demonstrated that supplements from this leaf reduced inflammatory markers like C-reactive protein, as well as oxidative stress markers like superoxide dismutase.
Although these results are encouraging, human studies are needed.
Although research is limited, mulberry leaf may offer several other health benefits. These include:
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